Toad venom, (5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) psychedelic drug improves depression and anxiety when administered in a structured group setting. A single smoked hit of the dried psychedelic secretion of a certain North American toad can potentially improve a person’s mental health. The substance in question is called 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), which was initially discovered in the bark of a plant. Researchers later realized the Bufo alvarius toad, more commonly known as the Colorado river toad, secretes a poisonous, milky-white substance in its skin and glands that also contains the 5-MeO-DMT compound.

People who smoke 5-MeO-DMT report having mystical-type experiences, characterized by awe, amazement, intense self-awareness and timelessness, among other effects.